Factor V Leiden and the Symptoms
There are reasons to ask for testing of the Factor V Leiden mutation and the PT 202010 test:
* When it is suspected that a person has an inherited risk factor for thrombosis
* When a patient has a first deep venous thrombosis (DVT) before age 50
* When a patient experinces a thromboembolism (VTE) before the age 50
* When a patient experiences either in an unusual part of the body
* The tests may be ordered when a person has a personal or family history of recurrent DVT,
or VTE
* A VTE related to oral contraceptive use, pregnancy or hormone replacement therapy
* Or experiencing unexplained miscarriages, especially those occurring in the second or last trimester of pregnancy.
* When a family member of first-degree is known to have Factor V Leiden or PT 20210
Note: If a symptomatic family member know that they have one or more of the mutations, they may be motivated to address controllable clotting risk factors such as oral contraceptive use, smoking, and elevated levels of homocysteine and be more aware of the potential risks of factor(s) triggering events, such as immobilization and surgery. However, many of those with the mutation will never experience a DVT or VTE.
Once APC resistance testing, factor V Leiden mutation testing, and PT 20210 gene mutation testing have been done, they are usually not repeated unless there is a need for verification.
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